Mrna Drug Production System

Chanse can supply the corresponding equipment for the preparation and linearization of mRNA drug plasmids, as well as for LNP and other processes.

Scope of Supply

Single-use mixer or reactor is available for linearizing,in vitro transcription,capping,tailing,and DNA degradation of plasmids.Enrichment and purification of mRNA can be performed by chromatography.

Ultrafiltration can be done by either ultrafiltration Cassettes or hollow fibers.LNP concentration and exchange can be performed by TFF.Finally,sterilization and filtration can be done by the filter.

Features

It can be applied to lab scale,pilot scale and industrialized production;

The key components of the chromatography system are all imported,with accurate data and stable performance.

Chromatography and ultrafiltration system has reasonable design,compact structure and small footprint.The pipelines is not easy to accumulate residual,which is easy to be cleaned;

The preparation of LNP is carried out by microfluidic which provides a controllable and stable mixing process with high mixing efficiency.The nanoparticles have uniform particle size and minimal batch-to-batch variation.

The key parameters of the process can be controlled to ensure the controllability of the preparation process.

The equipment can meet the GMP requirements,and the system has CIP/SIP function