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  • Pharma Twin Screw Extruder

    Thermo Scientific™ pharmaceutical twin-screw extruder, with powerful modular design and flexible plug-in, has the following four functions at the same time: 

     

    · Pharma hot melt extrusion

    · Continuous wet granulation and extrusion

    · Roller Compactor

    · Extruder and Spheronizer

     

     

    It has many advantages besides the widely known applications. By switching inserts and modules, the existing thermo twin-screw extruder mode can be adjusted to wet extruder, roller compactor, extruder and spheronizer mode, which greatly reduces the investment in new equipment, increases the equipment utilization rate, greatly reduces the equipment maintenance cost and saves the space occupied by laboratory equipment.

     

    Minimize Effort and Time When Scaling Up

    By utilizing Pharma twin-screw extruders suitable for HME and TSG, we are able to achieve reliable scale-up production, shorten product time-to-market, and control the continuous processing. A successful scale-up begins with precision-designed extruders to ensure geometric similarity of the entire product line.

    We adopt a "quality-by-design" approach to ensure a comprehensive understanding of the new process, thus minimizing your time, number of steps, and materials while achieving the scale-up goals.

    Less effort to develop and scale up Screw elements and barrel design scale geometrically across all Thermo Scientific Pharma twin-screw extruders, allowing easy process scale up.

    Quick conversion from HME to TSG Modularity of extruder software and hardware systems allows you to switch continuous processes to fit your formulation challenges.

    Fast and easy cleaning between runs The segmented screw and barrel design allow for fast disassembly, making it easy to remove residue and support your cleaning validation.

    Waste less material Twin-screw geometries maximize throughput, efficiently using expensive APIs for formulation development.

    Specification

    Pharma Twin Screw Extruder

    Pharma Twin-Screw Extruders Pharma mini HME Pharma 11 Pharma 16 Pharma 24
    Recommended for Feasibility Research Phase 1 Pilot Phase 2 Manufacturing Phase 3
    HME Y Y Y Y
    Wet granulator - Y Y Y
    Extruder and spheronizer - Y Y Y
    Roller compactor - Y Y Y
    （kg/h）Typical  Throughput ★ up to3 up to15 up to60
    Dimensions  (L × W × H) 650×470×590 820×480×410 1750X610×1220 1900×800×1300
    Screw Design Conical, Co-/Counterrotating Parallel, Co-Rotating Parallel, Co-Rotating Parallel, Co-Rotating

     

    All of our equipment is made of pharma-grade stainless steel and allow you to meet GMP compliance with access to full validation (e. g. , FAT, SAT, IQ/OQ).

    （All rights for changes reserved.）

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